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Many of you know that I like to fish and enjoy eating the fi

Many of you know that I like to fish and enjoy eating the fish I catch. But, there is one fish consi… Show more Many of you know that I like to fish and enjoy eating the fish I catch. But, there is one fish considered a delicacy in Japan that I don’t think I would eat even if I were in a fancy Japanese restaurant. It’s called a puffer fish and it contains tetrodotoxin which is 100 times more deadly than cyanide. I am told that puffer fish, if prepared by an expert, can contain just enough of the toxin so that you can feel it, but not enough to hurt you. Your job is to explain why this molecule is do deadly. I want to know what molecule tetrodotoxin binds to (what does it look like, where is it located) and at what affinity does it bind. Tell me about the functions of the molecule that gets inhibited by the toxin and what the physiological effects are. Why are the serious effects more limited to one major organ system when this molecule is found in many cell types? • Show less


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